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L-Methionine - technical card
PHYSIOLOGICAL URINARY ACIDIFYING
PROPERTY
L-Methionine is one of the essential amino acids: an important element of the human organism. Furthermore, L-Methionine is the only essential amino acid that contains sulfur in its formula. The availability of L-Methionine (as a donor of sulfur) in sufficient quantity is the necessary condition for the biosynthesis of cysteine, an amino acid disulphide. The -SH group of cysteine is oxidized to sulfate in the liver and is eliminated by the kidneys. At the same time of sulfate, protons will appear into the lumen of the tubules. This physiological process is the basis of the urine acidification obtained from L-Methionine. A large number of Gram-negative bacteria are capable to alkalinize urine by enzymatic degradation of urea and can create conditions favorable for growth. The acidifying effect of L-methionine causes a shift of urinary pH in the range of pH between 5.4 and 6.2. This acidic environment reduces the adhesion of bacterial pathogens to urothelium cells and inhibits the growth of bacterial strains. A chronic urinary tract infection with alkaline urine can induce the formation and growth of phosphates stones. The acidification of the urine with L-Methionine improves the solubility of the stones and is an essential principle to prevent the formation of new stones.
PHARMACOKINETICS
Absorption: The L-methionine is absorbed almost completely by the mucous of the median of the small intestine, thanks to a protein which transports preferentially neutral amino acids.
Distribution: From mucosal cells, L-methionine passes into the blood and reaches the liver through the portal vein. In the liver products of metabolism physiologically active be formed as needed..
Metabolism: When the reserves of glutathione are complete, the sulfur of L-methionine is mostly oxidized to sulfate (about 90%) generating the acidification of urine.
Elimination: After oral intakes of 300 mg. rates of plasma L-Methionine will increase in half an hour from 12 µmmol / to 35 µmol / l and return to their initial value in about 8 hours. The half-life is between 1 and 1.5 hours. Approximately 5-10% of the amount of L-Methionine administered appears in the urine in unchanged form. The administration of 500 mg. 3 times / day can increase the urinary elimination of sulfate from 16 mmol to 25 mmol in 24 hours.
INDICATIONS
Acidification of urine in cases of chronic urinary tract infections. Phosphate Stones.
PROPERTY
L-Methionine is one of the essential amino acids: an important element of the human organism. Furthermore, L-Methionine is the only essential amino acid that contains sulfur in its formula. The availability of L-Methionine (as a donor of sulfur) in sufficient quantity is the necessary condition for the biosynthesis of cysteine, an amino acid disulphide. The -SH group of cysteine is oxidized to sulfate in the liver and is eliminated by the kidneys. At the same time of sulfate, protons will appear into the lumen of the tubules. This physiological process is the basis of the urine acidification obtained from L-Methionine. A large number of Gram-negative bacteria are capable to alkalinize urine by enzymatic degradation of urea and can create conditions favorable for growth. The acidifying effect of L-methionine causes a shift of urinary pH in the range of pH between 5.4 and 6.2. This acidic environment reduces the adhesion of bacterial pathogens to urothelium cells and inhibits the growth of bacterial strains. A chronic urinary tract infection with alkaline urine can induce the formation and growth of phosphates stones. The acidification of the urine with L-Methionine improves the solubility of the stones and is an essential principle to prevent the formation of new stones.
PHARMACOKINETICS
Absorption: The L-methionine is absorbed almost completely by the mucous of the median of the small intestine, thanks to a protein which transports preferentially neutral amino acids.
Distribution: From mucosal cells, L-methionine passes into the blood and reaches the liver through the portal vein. In the liver products of metabolism physiologically active be formed as needed..
Metabolism: When the reserves of glutathione are complete, the sulfur of L-methionine is mostly oxidized to sulfate (about 90%) generating the acidification of urine.
Elimination: After oral intakes of 300 mg. rates of plasma L-Methionine will increase in half an hour from 12 µmmol / to 35 µmol / l and return to their initial value in about 8 hours. The half-life is between 1 and 1.5 hours. Approximately 5-10% of the amount of L-Methionine administered appears in the urine in unchanged form. The administration of 500 mg. 3 times / day can increase the urinary elimination of sulfate from 16 mmol to 25 mmol in 24 hours.
INDICATIONS
Acidification of urine in cases of chronic urinary tract infections. Phosphate Stones.
